A MIMO wireless communication device includes, in part, a first transmit path adapted to transmit a first transmit signal from a first antenna, a second transmit path adapted to transmit a second transmit signal from a second antenna, a first receive path adapted to receive a first receive signal, an interference cancellation circuit and a controller. The cancellation circuit includes a cascaded filter structure each filter including a multitude of filter taps each including a variable element. The controller dynamically varies a value applied to each of the plurality of variable elements in accordance with frequency response characteristics of the variable element to remove a portion of a self-interference and/or cross-talk interference signal present in a signal received by the device. The device measures the frequency response characteristic of a multitude of communication channels, used in determining the values, via one or more preamble symbols that are jointly transmitted from the first transmit antenna and the second transmit antenna. A second portion of the interference signal is removed by a digital cancellation circuit using a multitude of samples of a transmitted signal.