Invention Grant
- Patent Title: Pharmaceutical compositions comprising nitroxyl donors
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Application No.: US14761934Application Date: 2014-01-17
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Publication No.: US10245249B2Publication Date: 2019-04-02
- Inventor: Vincent Jacob Kalish , John Reardon , Frederick Arthur Brookfield , Stephen Martin Courtney , Lisa Marie Frost , John P. Toscano
- Applicant: Cardioxyl Pharmaceuticals, Inc.
- Applicant Address: US NC Chapel Hill
- Assignee: Cardioxyl Pharmaceuticals, Inc.
- Current Assignee: Cardioxyl Pharmaceuticals, Inc.
- Current Assignee Address: US NC Chapel Hill
- Agency: Byrne Poh LLP
- Agent Nina R. Horan
- International Application: PCT/US2014/012089 WO 20140117
- International Announcement: WO2014/113700 WO 20140724
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/08 ; A61K31/18 ; A61K31/24 ; A61K47/12 ; A61K47/40 ; A61K31/222 ; A61K31/255 ; A61K31/341 ; C07D307/64 ; A61K31/42 ; A61K31/343 ; A61K31/381 ; A61K31/404 ; A61K31/433 ; A61K31/538 ; A61K31/4436 ; A61K31/5377 ; C07C317/14
Abstract:
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.
Public/Granted literature
- US20150366977A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS Public/Granted day:2015-12-24
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