Invention Grant
- Patent Title: Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
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Application No.: US15392173Application Date: 2016-12-28
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Publication No.: US10245288B2Publication Date: 2019-04-02
- Inventor: Joseph E. Kovarik
- Applicant: Joseph E. Kovarik
- Agency: Sheridan Ross P.C.
- Main IPC: A61F5/00
- IPC: A61F5/00 ; A61K35/741 ; A61K35/745 ; A61K35/747

Abstract:
A method for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease that involves providing an individual with an effective amount of a composition of bacteria modified using a Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated system (CRISPR-Cas) or Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella 1 (CRISPR/Cpf1) system so that the bacteria is able to produce a therapeutically effective amount of anti-bodies to oxidized low density lipoprotein, with the modified bacteria preferably being from the Lactobacillus, Bifidobacterium, and Streptococcus species; and most preferably including L. reuteri bacteria modified using CRISPR-Cas and/or Cpf1 systems so that it is able to survive the conditions in the duodenum and jejunum of the small intestine of a human.
Public/Granted literature
- US20170106026A1 Method and System for Treating Non-Alcoholic Fatty Liver Disease Public/Granted day:2017-04-20
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