A multi-axis rotational puzzle cube has a core unit and multiple first operating assemblies and multiple second operating assemblies rotatably assembled to the core unit. Each one of the multiple first operating assemblies has a first operating unit connected to the core unit, a snap rivet connected to the first operating unit inside the core unit, a blocking tube mounted around and stuck with the snap rivet, and a compression spring mounted around the snap rivet and abutting against the core unit and the blocking tube simultaneously. Each one of the multiple second operating assemblies has a second operating unit connected to the core unit, a snap rivet connected to the second operating unit inside the core unit, a blocking tube mounted around and stuck with the snap rivet, and a compression spring mounted around the snap rivet and abutting against the core unit and the blocking tube simultaneously.