Invention Grant
- Patent Title: Modulators of calcium release-activated calcium channel
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Application No.: US15892229Application Date: 2018-02-08
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Publication No.: US10246450B2Publication Date: 2019-04-02
- Inventor: Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
- Applicant: Rhizen Pharmaceuticals SA
- Applicant Address: CH La Chaux-de-Fonds
- Assignee: RHIZEN PHARMACEUTICALS SA
- Current Assignee: RHIZEN PHARMACEUTICALS SA
- Current Assignee Address: CH La Chaux-de-Fonds
- Agency: Blank Rome LLP
- Priority: IN2439/CHE/2009 20091008; IN2636/CHE/2009 20091030; IN158/CHE/2010 20100125; IN1513/CHE/2010 20100602; IN1514/CHE/2010 20100602
- Main IPC: C07D417/10
- IPC: C07D417/10 ; A61K31/415 ; A61K31/422 ; A61K31/433 ; A61K31/4439 ; A61K31/455 ; A61K31/496 ; A61K31/506 ; A61K31/5377 ; A61K45/06 ; C07D207/327 ; C07D207/337 ; C07D231/12 ; C07D295/195 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/10 ; C07D403/12 ; C07D403/14 ; C07D413/10 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C12N5/078 ; A61K31/427
Abstract:
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
Public/Granted literature
- US20180222898A1 NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL Public/Granted day:2018-08-09
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