Invention Grant
- Patent Title: Thienopyrimidine and thienopyridine compounds and methods of use thereof
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Application No.: US15509989Application Date: 2015-09-08
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Publication No.: US10246464B2Publication Date: 2019-04-02
- Inventor: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jonathan Pollock , Hongzhi Miao , Duxin Sun , Liansheng Li , Tao Wu , Jun Feng , Pingda Ren , Yi Liu
- Applicant: The Regents of the University of Michigan , Kura Oncology, Inc
- Applicant Address: US MI Ann Arbor US CA La Jolla
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,KURA ONCOLOGY, INC.
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,KURA ONCOLOGY, INC.
- Current Assignee Address: US MI Ann Arbor US CA La Jolla
- Agency: Casimir Jones SC
- Agent David W. Staple
- International Application: PCT/US2015/048957 WO 20150908
- International Announcement: WO2016/040330 WO 20160317
- Main IPC: C07D495/04
- IPC: C07D495/04 ; C07D519/00 ; C07F9/53 ; C07F9/6558
Abstract:
The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used in methods for the treatment of a wide variety of cancers and other diseases associated with one or more of MLL1, MLL2, MLL fusion proteins, and menin.
Public/Granted literature
- US20170247391A1 THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF Public/Granted day:2017-08-31
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