Invention Grant
- Patent Title: Method for producing pluripotent stem cell having improved chimera forming ability from primed pluripotent stem cell, and composition and combination therefor
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Application No.: US14635331Application Date: 2015-03-02
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Publication No.: US10246679B2Publication Date: 2019-04-02
- Inventor: Hiromitsu Nakauchi , Hideki Masaki , Hideyuki Murayama
- Applicant: The University of Tokyo
- Applicant Address: JP Tokyo
- Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee Address: JP Tokyo
- Agency: Pearne & Gordon LLP
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N15/74 ; C12N5/0735 ; A01K67/027 ; C12N15/85
Abstract:
The present invention provides a method for putting a primed pluripotent stem cell in a less differentiated state, a method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, and a method for producing a chimeric animal by using the pluripotent stem cell obtained by any of these methods. The present invention also provides a composition containing a Wnt/β catenin signal inhibitor.
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