Invention Grant
- Patent Title: Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
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Application No.: US14783391Application Date: 2014-04-10
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Publication No.: US10246694B2Publication Date: 2019-04-02
- Inventor: Zachary Q. Beck , Jeffrey W. Munos , Derek H. Wells , Jian Yao
- Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
- Applicant Address: US CA Palo Alto US OH Akron
- Assignee: DANISCO US INC.,THE GOODYEAR TIRE & RUBBER COMPANY
- Current Assignee: DANISCO US INC.,THE GOODYEAR TIRE & RUBBER COMPANY
- Current Assignee Address: US CA Palo Alto US OH Akron
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
- International Application: PCT/US2014/033688 WO 20140410
- International Announcement: WO2014/169144 WO 20141016
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12P5/02 ; C12P19/32 ; C12P5/00 ; C12Q1/527
Abstract:
This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
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