Multi-resolution fingerprint sensors and methods of using the same are provided. The multi-resolution fingerprint sensors each include a portion of the imaging area or region of the sensor that provides higher imaging resolution than the remaining imaging area of the sensor. The area of higher resolution is useful for anti-spoofing purposes, but because only a portion of the sensor is higher-resolution, advantageously it will not impact hardware costs nearly as much as a sensor that was higher resolution over its entire imaging area. Furthermore, the higher resolution area can be down-sampled so there would be no impact on the standard matcher and image processing software stack, which expects a uniform resolution for the entire image acquired.