Method and system for detecting and tracking multiple moving targets based on wide-area motion imagery are provided. The method includes receiving a task request from a client; sending the task request to a local agent; acquiring to-be-processed images from the client, in response to the task request; calling an Hadoop API and checking a running status of a Hadoop system for an available resource in the Hadoop system; when a resource in the Hadoop system is available, pushing the to-be processed images to a back-end Hadoop distributed file system (HDFS); running tracking algorithms of multiple moving objects associated with the to-be-processed images to provide tracking results of the multiple moving objects; when the Hadoop system is completed in running the tracking algorithms, generating and sending a message to the local agent; and sending the tracking results of the multiple moving objects from the HDFS to the front-end database.