A multi-node motion measurement and analysis system comprises at least one motion measurement module and a receiver unit. The motion measurement module is bound to a hand-held sports appliance through an adjustable fixture or being bound to a human body. A binding position on the human body is rearrangeable based on different measurement requirements. The motion measurement module comprises a sensor module configured to measure information of acceleration, angular velocity and magnetic force, a first microprocessor module connected to the sensor module and configured to generate information of orientation, and a first RF module configured to receive the information of acceleration, angular velocity, magnetic force and orientation and transmit the received information to the receiver unit. The receiver unit generates motion information according to the information of acceleration, angular velocity, magnetic force and orientation, and calibrates the motion measurement module bound to different positions on the human body.