An environment cleaning system for an animal breeding house has an outside environment, a breeding house, an air covering, and a cleaning device. The breeding house is deposited in the outside environment. The air covering is deposited in the outside environment and is mounted around the breeding house. The air covering is used to buffer the air pressure between the outside environment and the breeding house. The cleaning device is deposited in the outside environment, is connected to the air covering and the breeding house, and has an air exchanging unit and at least one filtering unit. The air exchanging unit controls the relative pressure among the outside environment, the air covering, and the breeding house to provide a unidirectional air flowing effect, and the flowing direction of the air is based on the relative pressure between the breeding house and the air covering.