A gas-liquid separation apparatus suitable for gas hydrate slurry, comprising an upper chamber, a middle chamber, and a lower chamber; a gas-phase outlet and a pressurizing unit are disposed in a top of the upper chamber, the middle chamber is provided with a material inlet and a wire mesh demister, and the lower chamber is provided with a liquid-phase outlet and a plurality of deflector baffles. The arrangement of divided chambers can reduce the degree of hydrate dissociation in the slurry (i.e., loss of the sought gas) and improve the separation efficiency. With the pressurizing unit, it facilitates the setting of the required pressure for gas-liquid separation without introducing a pressure maintaining valve in the subsequent separation process, prevents the hydrate in the slurry from dissociating in the apparatus, and allows rapid separation between the slurry and the gas.