A thermal comfort system for use with a vehicle seat includes an airflow management system and a thermal-electric device (TED) system. The TED system operates to conduct thermal energy between the seat occupant and the vehicle seat to enhance the thermal comfort of the seat occupant. The airflow management system operates to route a stream of conditioned air along the body of the seat occupant via cooperating air intake and air discharge ports to further enhance the comfort of the seat occupant. The conditioned air may also be routed along the TED system to enhance TED performance. The HVAC system of the vehicle can provide the conditioned air and/or a non-ambient pressure source that induces air flow along one or more portions of the thermal comfort system.