A method for delivering items in a pneumatic delivery system includes receiving delivery information corresponding to an item to be delivered from a first workstation of a plurality of workstations to a second one of the workstations, configuring a first one of a plurality of blowers and a corresponding workstation diverter corresponding to the first workstation to create a path from the first workstation to the first blower, operating the first blower to generate suction drawing the item to the first blower, configuring a subset of the plurality of diverters of the system to create a continuous path from the first blower to the second workstation and routing, when the first and second workstations are in separate subsystems of the pneumatic delivery system, the item through an inter-subsystem exchange unit so that the item is delivered to the second workstation using only the first blower.