Invention Grant
- Patent Title: Drug with antiviral activity (variants)
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Application No.: US15564009Application Date: 2016-04-06
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Publication No.: US10253037B2Publication Date: 2019-04-09
- Inventor: Viktor Veniaminovich Tets , Georgy Viktorovich Tets , Konstantin Andreevich Krasnov
- Applicant: Viktor Veniaminovich Tets , Georgy Viktorovich Tets
- Applicant Address: RU St. Petersburg RU St. Petersburg
- Assignee: Viktor Veniaminovich Tets,Georgy Viktorovich Tets
- Current Assignee: Viktor Veniaminovich Tets,Georgy Viktorovich Tets
- Current Assignee Address: RU St. Petersburg RU St. Petersburg
- Agency: Troutman Sanders LLP
- Priority: RU2015113254 20150403
- International Application: PCT/RU2016/000197 WO 20160406
- International Announcement: WO2016/159836 WO 20161006
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D491/147 ; A61P31/20 ; A61P31/18 ; A61K31/513 ; A61K31/7072

Abstract:
The invention relates to the field of organic chemistry and medicine, and more particularly to synthetic substances of the pyrimidine series, namely 2-chloro-5-phenyl-5H-pyrimido[5′,4′:5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives, having antiviral activity. Claimed are a drug with antiviral activity against HIV infection and hepatitis B virus, containing 2-chloro-5-phenyl-5H-pyrimido[5′,4′:5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives of the general formula shown, where: X is selected from the group: H, NO2, Hal, OMe; R1 is selected from the group: Cl, OH; and R2 is selected from the group: Cl, SH, OH; and a drug with antiviral activity against HIV infection, containing a 2-chloro-5-phenyl-5H-pyrimido[5′,4′:5,6]pyrano[2,3-d]pyrimidine-4-ol derivative of the general formula shown, where: X is selected from the group: H, NO2, Hal, OMe; R1 is selected from the group: Cl, OH; and R2 is selected from the group: Cl, SH, OH in combination with a reverse transcriptase inhibitor selected from Retrovir, or in combination with a protease inhibitor selected from Lopinavir, in an effective amount. The result is an effective drug with antiviral activity.
Public/Granted literature
- US20180134723A1 DRUG WITH ANTIVIRAL ACTIVITY (VARIANTS) Public/Granted day:2018-05-17
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