Invention Grant
- Patent Title: Modified von Willebrand Factor
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Application No.: US15323401Application Date: 2015-07-02
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Publication No.: US10253088B2Publication Date: 2019-04-09
- Inventor: Michael Wilson , Steve Dower , Dallas Hartman , Mathew Hardy
- Applicant: CSL Behring Lengnau AG
- Applicant Address: CH Lengnau BE
- Assignee: CSL Behring Lengnau AG
- Current Assignee: CSL Behring Lengnau AG
- Current Assignee Address: CH Lengnau BE
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: AU2014902532 20140702
- International Application: PCT/AU2015/050369 WO 20150702
- International Announcement: WO2016/000039 WO 20160107
- Main IPC: A61P7/04
- IPC: A61P7/04 ; A61K38/00 ; A61K38/36 ; A61K38/37 ; C07K14/755 ; C07K14/765

Abstract:
The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least a modification at position 1 or 3 such that the modified polypeptide binds to Factor VIII with an off rate at least 5 fold lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.
Public/Granted literature
- US20170152300A1 MODIFIED VON WILLEBRAND FACTOR Public/Granted day:2017-06-01
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