Invention Grant
- Patent Title: Matrix metalloproteinase cleavable protein polymers for cancer gene therapy
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Application No.: US14403979Application Date: 2013-05-30
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Publication No.: US10253089B2Publication Date: 2019-04-09
- Inventor: Hamidreza Ghandehari , Joseph Cappello , Jordan Frandsen , Joshua Gustafson , Khaled Greish , Robert Andrew Price
- Applicant: The University of Utah Research Foundation
- Applicant Address: US UT Salt Lake City
- Assignee: University of Utah Research Foundation
- Current Assignee: University of Utah Research Foundation
- Current Assignee Address: US UT Salt Lake City
- Agency: Gardner Groff Greenwald & Villanueva, PC
- International Application: PCT/US2013/043487 WO 20130530
- International Announcement: WO2013/181471 WO 20131205
- Main IPC: A61K38/39
- IPC: A61K38/39 ; A61K47/42 ; A61K48/00 ; C07K14/78 ; A61K47/66 ; A61K47/65 ; C07K14/435 ; A61K31/522 ; A61K38/45 ; C12N7/00 ; A61K47/64
Abstract:
A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.
Public/Granted literature
- US20150152165A1 MATRIX METALLOPROTEINASE CLEAVABLE PROTEIN POLYMERS FOR CANCER GENE THERAPY Public/Granted day:2015-06-04
Information query
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