Invention Grant
- Patent Title: Conjugates of proteins and multivalent cell-penetrating peptides and their uses
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Application No.: US14648537Application Date: 2013-12-04
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Publication No.: US10253099B2Publication Date: 2019-04-09
- Inventor: Matthias Strieker , Walter Mier , Uwe Haberkorn
- Applicant: Ruprecht-Karls-Universitaet Heidelberg
- Applicant Address: DE Heidelberg
- Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
- Current Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
- Current Assignee Address: DE Heidelberg
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/EP2013/075494 WO 20131204
- International Announcement: WO2014/086835 WO 20140612
- Main IPC: A61K47/56
- IPC: A61K47/56 ; A61K47/64 ; A61K51/08 ; A61K51/10 ; C07K16/28
Abstract:
The present invention relates to conjugates comprising a protein and multivalent cell-penetrating peptide(s), each multivalent cell-penetrating peptide comprising at least two cell-penetrating peptides, wherein the multivalent cell-penetrating peptide(s) is/are covalently attached to the protein. The present invention furthermore relates to a method of generating the conjugates and to their medical uses, in particular their use in the diagnosis, prevention and/or treatment of diseases. The present invention relates to methods of diagnosis, prevention and/or treatment of diseases, comprising administering the conjugates of the invention to a patient.
Public/Granted literature
- US20150297742A1 Conjugates of Proteins and Multivalent Cell-Penetrating Peptides and Their Uses Public/Granted day:2015-10-22
Information query
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