Invention Grant
- Patent Title: Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance
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Application No.: US14347187Application Date: 2012-09-28
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Publication No.: US10253100B2Publication Date: 2019-04-09
- Inventor: Tomoyuki Igawa , Atsuhiko Maeda , Futa Mimoto , Taichi Kuramochi
- Applicant: Chugai Seiyaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2011-218736 20110930; WOPCT/JP2012/058603 20120330; JP2012-123773 20120530; JP2012-123781 20120530; JP2012-123782 20120530; JP2012-139211 20120620; JP2012-177311 20120809
- International Application: PCT/JP2012/006218 WO 20120928
- International Announcement: WO2013/046704 WO 20130404
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K39/00

Abstract:
The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules.
Public/Granted literature
- US20140363428A1 THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE Public/Granted day:2014-12-11
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