Invention Grant
- Patent Title: Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
-
Application No.: US15346332Application Date: 2016-11-08
-
Publication No.: US10253106B2Publication Date: 2019-04-09
- Inventor: Luigi Grasso , Nicholas C. Nicolaides , Philip M. Sass
- Applicant: Morphotek, Inc.
- Applicant Address: US NJ Woodcliff Lake
- Assignee: Eisai, Inc.
- Current Assignee: Eisai, Inc.
- Current Assignee Address: US NJ Woodcliff Lake
- Agency: Baker & Hostetler LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; B82Y5/00 ; A61K31/704 ; A61K31/7068 ; A61K39/395 ; C07K16/22 ; A61K47/68

Abstract:
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (FRA) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to FRA-expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer cells; and methods of treating cancer using the antibodies.
Public/Granted literature
- US20170073425A1 Antibodies With Immune Effector Activity and That Internalize In Folate Receptor Alpha-Positive Cells Public/Granted day:2017-03-16
Information query