Invention Grant
- Patent Title: Chemical reprogramming of human glial cells into neurons with small molecule cocktail
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Application No.: US15828652Application Date: 2017-12-01
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Publication No.: US10253293B2Publication Date: 2019-04-09
- Inventor: Gong Chen , Lei Zhang , Jiuchao Yin , Ningxin Ma
- Applicant: The Penn State Research Foundation
- Applicant Address: US PA University Park
- Assignee: The Penn State Research Foundation
- Current Assignee: The Penn State Research Foundation
- Current Assignee Address: US PA University Park
- Agency: Hodgson Russ LLP
- Main IPC: A61K33/14
- IPC: A61K33/14 ; A61K31/192 ; A61K31/375 ; A61K31/506 ; A61K31/4418 ; A61K31/4545 ; C12N5/0793
Abstract:
Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.
Public/Granted literature
- US20180148688A1 CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS WITH SMALL MOLECULE COCKTAIL Public/Granted day:2018-05-31
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