Invention Grant
- Patent Title: Visualizing modified nucleotides and nucleic acid interactions in single cells
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Application No.: US15534334Application Date: 2015-12-22
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Publication No.: US10253356B2Publication Date: 2019-04-09
- Inventor: Vikas Palhan , Carol Kreader
- Applicant: SIGMA-ALDRICH CO. LLC
- Applicant Address: US MO St. Louis
- Assignee: Sigma-Aldrich Co. LLC
- Current Assignee: Sigma-Aldrich Co. LLC
- Current Assignee Address: US MO St. Louis
- Agent Benjamin J. Sodey
- International Application: PCT/US2015/067316 WO 20151222
- International Announcement: WO2016/106298 WO 20160630
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6841 ; C12N15/09 ; G01N33/50
Abstract:
Methods for visualizing modified nucleotides in a specific nucleic acid sequence or specific nucleic acid sequence interactions in single cells, wherein the methods comprise coupling an in situ hybridization (ISH) reaction with a proximity ligation assay (PLA) reaction.
Public/Granted literature
- US20170362647A1 VISUALIZING MODIFIED NUCLEOTIDES AND NUCLEIC ACID INTERACTIONS IN SINGLE CELLS Public/Granted day:2017-12-21
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