Provided is a method of manufacturing a grain-refined aluminum-zinc-magnesium-copper alloy sheet, including manufacturing an aluminum alloy sheet from an aluminum-zinc-magnesium-copper alloy melt by twin-roll strip casting, primarily rolling the aluminum alloy sheet manufactured in step 1, cold rolling the aluminum alloy sheet manufactured in step 2, and performing a heat treatment on the aluminum alloy sheet manufactured in step 3, thereby reducing processing time and cost by using twin-roll casting. Since grain refinement and homogenization of the sheet manufactured by the twin-roll casting are maximized by sequentially performing warm rolling, cold rolling, and a heat treatment on the sheet, elongation may be improved.