A system for analyzing an engine of a vehicle may comprise a computer including a computer processor, a sensor connected to a portion of the vehicle and being configured to provide an engine signature to the computer, a simulator module configured to utilize the computer processor to generate simulated signature features associated with a simulated vehicle having prescribed defects, and a self-learning module configured to utilize the computer processor to learn associations between the simulated signature and prescribed defects. The computer processor may be configured to compare the engine signature with the associations of the self-learning module to produce a probability indicator that the engine has the prescribed defect at a specified intensity associated with a diagnosis of the engine.