Disclosed is a system to control a climate of a space via a first control loop and a second control loop interacting with the first control loop. The system includes a first controller of the first control loop to generate a first control signal based on a first modified set point and a first feedback signal. The system further includes a second controller of the second control loop to generate a second control signal based on a second modified set point and a second feedback signal. The system further includes a decoupler configured to predict a first effect of the first control signal on the second control loop and a second effect of the second control signal on the first control loop, and generate the first modified set point and the second modified set point to reduce the first effect and the second effect.