A system can accommodate riders of a transportation arrangement service that have certain physical impairments, such as visual, hearing, or movement impairments. In certain aspects, a transportation facilitation system can create rider profiles that specify a particular impairment, and vehicle profiles indicating accommodation features. The transport facilitation system can receive a pick-up request, utilize the rider profile and vehicle profiles of vehicle proximate to a pick-up location, select a vehicle to service the pick-up request, and generate a configuration set to configure the selected vehicle to accommodate the impaired user.