The present disclosure relates to a pixel compensation circuit and an AMOLED display device. The pixel compensation circuit includes a data signal writing sub-circuit, a high voltage signal writing sub-circuit, a first reference voltage writing sub-circuit, a second reference voltage writing sub-circuit, a voltage maintaining sub-circuit, a driving transistor, a capacitor, and a light emitting device. The data signal writing sub-circuit is connected to a first terminal of the capacitor, the first reference voltage writing sub-circuit is connected to a control electrode of the driving transistor, and the second reference voltage writing sub-circuit is connected to a drain of the driving transistor. The high voltage signal writing sub-circuit is connected to a second terminal of the capacitor, and the voltage maintaining sub-circuit is connected to the first terminal of the capacitor and the control electrode of the driving transistor.