A sensing circuit includes a first sensing terminal, a second sensing terminal, a second grounding terminal, and a second grounding terminal. The first sensing terminal is connected to a source electrode of a transistor of a memory macro through a bit line. The second sensing terminal is electrically connected to a drain electrode of the transistor of the memory marco through a resistive memory device to a source line, and is not continuously connected to the grounding voltage. The first grounding terminal is used as a reference voltage of a voltage of the first sensing terminal. The second grounding terminal is used as a reference voltage of a voltage of the second sensing terminal. The sensing circuit outputs a sensing signal according to a voltage difference between the first sensing terminal and the second sensing terminal.