Various implementations described herein are directed to a circuit for translating an input signal from a source voltage domain to an output signal for a destination voltage domain that is is different than the source voltage domain. The circuit may include a level shifting portion configured to operate with a supply voltage that exceeds a stressing threshold of one or more components within the circuit. The level shifting portion may be configured to generate the output signal for the destination voltage domain based on the input signal and a power management signal. The circuit may include an isolating portion configured to isolate the one or more components from the supply voltage during activation and deactivation of the circuit based on the power management signal.