Systems and methods for determining priority levels to process vulnerabilities associated with a networked computer system can include a data collection engine receiving a plurality of specification profiles, each defining one or more specification variables of the networked computer system or a respective asset. The data collection engine can receive, from a vulnerability scanner, vulnerability data indicative of a vulnerability associated with the networked computer system. A profiling engine can interrogate a computing device of the networked computer system, and receive one or more respective profiling parameters from that computing device. A ranking engine can compute a priority ranking value of the computing device based on the profile specification variables, the vulnerability data and the profiling parameters. The priority ranking value associated with the computing device can be indicative of a priority level, compared to other computing devices of the computer network, for patching a vulnerability affecting that computing device.