A data distribution system in comprises software application nodes that utilize a publish-subscribe communication mechanism for distribution of data in real-time or near real-time within a personal area network (PAN), local area network (LAN), or wide-area network (WAN) configuration. The distributed system communication software application nodes reside in medical devices, such as monitoring devices and cardiac defibrillators, and associated patient information delivery systems and patient data management systems comprising medical software installed on servers and end-user computing devices, including mobile devices.