A detection device of a sample to be examined is described, including a processing module, a detecting module, connected to the processing module, a support, in which the sample to be examined can be placed, the support including a plurality of sensors, preferably biosensors and/or nanosensors, and being insertable within the detecting module, and a containment enclosure including a body, which is arranged within the processing module, and a sensor portion, in which the detecting module is arranged. The processing module includes a processing unit having a plurality of processing channels and a processor, each one of the processing channels being connected to one respective of the sensors and being adapted to amplify and to filter the signals of the sensors, the processor processing the signals amplified and filtered by the processing channels.