Invention Grant
- Patent Title: (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide for treatment of neurodegenerative diseases
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Application No.: US15578120Application Date: 2016-05-13
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Publication No.: US10259777B2Publication Date: 2019-04-16
- Inventor: Jianhui Rong
- Applicant: THE UNIVERSITY OF HONG KONG
- Applicant Address: CN Hong Kong
- Assignee: The University of Hong Kong
- Current Assignee: The University of Hong Kong
- Current Assignee Address: CN Hong Kong
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/CN2016/082007 WO 20160513
- International Announcement: WO2016/192525 WO 20161209
- Main IPC: C07C235/34
- IPC: C07C235/34 ; A61P25/28 ; A61P25/16 ; C07C231/10 ; C07C231/24 ; A61K38/18

Abstract:
The present invention pertains to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide of Formula (I): The invention also pertains to a method for stimulating neurite outgrowth by administering to cells in the area where neurite outgrowth is desired a therapeutically effective amount of the compound of Formula (I). Further, the invention pertains to a method for attenuating neuron injury in a subject by contacting a neuron in a subject in need thereof with a therapeutically effective amount of the compound of Formula (I). Furthermore, a method of preparing the compound of Formula (I) are provided.
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