Invention Grant
- Patent Title: Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity
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Application No.: US15686794Application Date: 2017-08-25
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Publication No.: US10259779B2Publication Date: 2019-04-16
- Inventor: Mary Kay Pflum
- Applicant: WAYNE STATE UNIVERSITY
- Applicant Address: US MI Detroit
- Assignee: WAYNE STATE UNIVERSITY
- Current Assignee: WAYNE STATE UNIVERSITY
- Current Assignee Address: US MI Detroit
- Agency: Brooks Kushman P.C.
- Main IPC: C07C259/06
- IPC: C07C259/06 ; A61K31/167 ; A61P35/00 ; A61P35/02
Abstract:
A compound having formula I for histone deacetylase inhibition is provided: or a pharmaceutically acceptable salt or hydrate thereof wherein R is alkyl, C6-18 aryl, C5-18 heteroaryl, C8-22 alkylaryl, C8-22 alkylheteroaryl, or halo.
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