Invention Grant
- Patent Title: Variants derived from ActRIIB and uses therefor
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Application No.: US15201031Application Date: 2016-07-01
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Publication No.: US10259861B2Publication Date: 2019-04-16
- Inventor: John Knopf , Jasbir Seehra , Ravindra Kumar
- Applicant: Acceleron Pharma Inc.
- Applicant Address: US MA Cambridge
- Assignee: ACCELERON PHARMA INC.
- Current Assignee: ACCELERON PHARMA INC.
- Current Assignee Address: US MA Cambridge
- Agency: White & Case LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/71 ; C07K14/72 ; C07K16/18 ; C07K14/705
Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
Public/Granted literature
- US20170058016A1 VARIANTS DERIVED FROM ACTRIIB AND USES THEREFOR Public/Granted day:2017-03-02
Information query
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