Invention Grant
- Patent Title: Protein modification of living cells using sortase
-
Application No.: US14890296Application Date: 2014-05-09
-
Publication No.: US10260038B2Publication Date: 2019-04-16
- Inventor: Lee Kim Swee , Hidde L. Ploegh
- Applicant: Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2014/037545 WO 20140509
- International Announcement: WO2014/183066 WO 20141113
- Main IPC: C12N5/07
- IPC: C12N5/07 ; A61K39/395 ; A61K47/68 ; A61K47/66 ; A61K47/65 ; C12N5/00 ; A61K39/00 ; C12N5/0783 ; C12N9/50
Abstract:
Non-genetically engineered mammalian cells modified by sortase-mediated conjugation of an agent thereto are provided. Methods of conjugating agents to nongenetically engineered mammalian cells using sortase are provided. Methods of using the cells, e.g. a method of modulating an immune response of a subject to an entity of interest, a method of neutralizing a substance in the body of a subject, a method of treating a subject in need of treatment for deficiency of a protein, and a method of treating a subject in need of treatment for a disease, are provided.
Public/Granted literature
- US20160122707A1 PROTEIN MODIFICATION OF LIVING CELLS USING SORTASE Public/Granted day:2016-05-05
Information query
