Invention Grant
- Patent Title: Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs)
-
Application No.: US15809470Application Date: 2017-11-10
-
Publication No.: US10260055B2Publication Date: 2019-04-16
- Inventor: Quan Lu , Qiyu Wang , Stanley N. Cohen
- Applicant: President and Fellows of Harvard College , The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US MA Cambridge US CA Stanford
- Assignee: President and Fellows of Harvard College,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: President and Fellows of Harvard College,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US MA Cambridge US CA Stanford
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K9/127
- IPC: A61K9/127 ; C07K7/06 ; C07K14/47 ; C07K19/00 ; C12N9/16 ; C12N9/22 ; C12N15/87 ; C12N9/00 ; A61K47/64
Abstract:
Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of cargo proteins, such as transcription factors, tumor suppressors, developmental regulators, growth factors, metastasis suppressors, pro-apoptotic proteins, nucleases, recombinases, and reprogramming factors into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
Public/Granted literature
- US20180119118A1 DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS) Public/Granted day:2018-05-03
Information query
