Invention Grant
- Patent Title: Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
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Application No.: US14066006Application Date: 2013-10-29
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Publication No.: US10260089B2Publication Date: 2019-04-16
- Inventor: Eriks Rozners , Thomas Zengeya
- Applicant: The Research Foundation for the State University of New York
- Applicant Address: US NY Binghamton
- Assignee: The Research Foundation of The State University of New York
- Current Assignee: The Research Foundation of The State University of New York
- Current Assignee Address: US NY Binghamton
- Agency: Tully Rinckey PLLC
- Agent Steven M. Hoffberg
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6839 ; C07K7/08 ; C07K9/00
Abstract:
Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.
Public/Granted literature
- US20140206838A1 COMPOSITIONS AND METHODS FOR RECOGNITION OF RNA USING TRIPLE HELICAL PEPTIDE NUCLEIC ACIDS Public/Granted day:2014-07-24
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