Invention Grant
- Patent Title: Competitive ligand binding assay for detecting neutralizing antibodies
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Application No.: US15031126Application Date: 2014-10-30
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Publication No.: US10261094B2Publication Date: 2019-04-16
- Inventor: Manoj Rajadhyaksha , Michael Partridge , Albert Torri
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Matthew Pavao
- International Application: PCT/US2014/063034 WO 20141030
- International Announcement: WO2015/066259 WO 20150507
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/68
Abstract:
A immunogenicity assay for detecting the presence of neutralizing antibodies to a biotherapeutic protein wherein the biotherapeutic protein has been administered to a patient in need, comprising the steps of (a) obtaining a sample from the patient; (b) incubating the sample in the presence of a capture reagent; and (c) adding a detecting reagent, wherein a decreased signal relative to a control sample indicates the presence of a neutralizing antibody to the biotherapeutic agent.
Public/Granted literature
- US20160252520A1 COMPETITIVE LIGAND BINDING ASSAY FOR DETECTING NEUTRALIZING ANTIBODIES Public/Granted day:2016-09-01
Information query
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