A touch display module having a pressure detection mechanism is provided. The touch display module includes a 3-D (three-dimensional) sensor and a 3-D controller. The 3-D sensor includes touch units and at least one pressure sensing unit. The 3-D controller includes a driver and a driving pulse processor. The driver provides a pressure scan pulse to the pressure sensing unit and a touch scan pulse to the touch units in combination with the driving pulse processor. The present disclosure further provides a driving method corresponding to the touch display module having the pressure detection mechanism including steps of: providing pressure scan pulses to the pressure sensing unit by the driver in combination with the driving pulse processor and providing touch scan pulses to the touch units in combination of the driving pulse processor by the driver.