Disclosed is an integrated circuit (IC) formation method, wherein trenches are formed within a semiconductor layer to define semiconductor mesa(s). Instead of immediately filling the trenches with an isolation material and performing a planarizing process to complete the STI regions prior to device formation, the method initially only form sidewall spacers within the trenches on the exposed sidewalls of the semiconductor mesa(s). After the sidewall spacers are formed, device(s) (e.g., field effect transistor(s), silicon resistor(s), etc.) are formed using the semiconductor mesa(s) and, optionally, additional device(s) (e.g., polysilicon resistor(s)) can be formed within the trenches between adjacent semiconductor mesas. Subsequently, middle of the line (MOL) dielectrics (e.g., a conformal etch stop layer and a blanket interlayer dielectric (ILD) layer) are deposited over the device(s), thereby filling any remaining space within the trenches and completing the STI regions. Also disclosed is an IC structure formed using the method.