Methods and systems for interference avoidance in a multi-protocol communication system may comprise receiving signals in a first communications protocol in a first frequency range and preventing interference signals from being generated in said first frequency range by configuring channel usage in a second communications protocol in a second frequency range based on said received signals. The configuring channel usage may include avoiding communicating in taboo channels and the received signals in said first communications protocol and signals in said configured channels in said second communications protocol may be communicated over one or more coaxial cables based on the configured channel usage. The taboo channels may be selected based on said received signals such that interference signals from said second frequency range do not occur in said first frequency range. The first frequency range comprises a cable or satellite television frequency range, or data over cable service interface standard (DOCSIS).