Post-operative apparel such as post-mastectomy garments are described herein. In various embodiments, a post-mastectomy garment may include first and second ends, an interior side and an exterior side opposite the interior side, and the interior and exterior sides may extend between the first and second ends. In some embodiments, a closing mechanism may releasably connect the first end to said second end. In various embodiments, two opposing openings through the garment may be provided and shaped to receive arms of a patient. In some embodiments, an adjustable chest support may extend outward from the interior side. One or more drain bulb pockets may be positioned on the interior side to receive one or more surgical drain bulbs. One or more tubing pockets may also be positioned on said interior side to receive excess drain tubing.