An air sanitization device is provided that utilizes radiant catalytic ionization to produce purifying plasma comprising highly oxidative molecules that greatly decrease the amount of volatile organic compounds, carbon monoxide and particulate matter within the HVAC system and the interior of transportation vehicle. The air sanitation device includes surfaces coated or impregnated with a noble alloy that comprises predominately titanium dioxide and a UV light source that directs UV light onto the surfaces of coated surfaces to generate, via the radiant catalytic ionization reaction the purifying plasma. Integration of the air sanitization device into a vehicle HVAC system greatly decreases irritant molecules within the vehicle.