A malleable cannula (50) for fluidically coupling with an anatomical structure includes a flexible cannula body wall (64) having a proximal end (68), a distal end (70), and a lumen (72) extending longitudinally between the proximal end (68) and the distal end (70). The proximal end (68) defines a first opening (80) to the lumen (72) and the distal end (70) defining a second opening (82) to the lumen (72). A channel is defined by a portion of the cannula body wall and extends longitudinally from the distal end (70) toward the proximal end (68). The channel has a first end oriented toward the proximal end of the cannula body wall. A malleable member (100) is provided within the channel and is fixedly connected to the cannula body wall (64) at the first end of the channel. The malleable member (100) is configured to assume and maintain a formed shape of the cannula body wall (64).