The manufacturing method of the honeycomb structure includes a mounting step of mounting an extruded honeycomb formed body on a firing setter disposed on a shelf plate, and a firing step of firing the honeycomb formed body mounted on the firing setter to form the honeycomb structure, and in the mounting step, the firing setter is used in which a value obtained by dividing an area of a formed body end face of the honeycomb formed body by an area of a honeycomb mounting surface of the firing setter which faces the formed body end face and at least a part of which comes in contact with the formed body end face is in a range of 2.5 to 20.0.