A ground drive hose routing system and method for a self-propelled agricultural product applicator utilize drive hose bulkhead connection arrangements mounted on transversely movable axle members to define segments of a hose arrangement that are constrained to lie and move primarily in only one direction, to isolate horizontal hose movement related to track-width adjustment from vertical hose movement resulting from action of suspension members. For steerable wheels, an additional pivotable segment is utilized in conjunction with the drive hose bulkhead connection arrangements to accommodate turning motion while maintaining isolation between other primarily horizontally and vertically constrained movable segments of the hose arrangement.