Invention Grant
- Patent Title: Human progenitor T-cells into NK cells
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Application No.: US15357029Application Date: 2016-11-21
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Publication No.: US10266805B2Publication Date: 2019-04-23
- Inventor: Juan Carlos Zuniga-Pflucker , Geneve Awong , Ross La Motte-Mohs
- Applicant: Sunnybrook Health Sciences Centre
- Applicant Address: CA Toronto, Ontario
- Assignee: Sunnybrook Health Sciences Centre
- Current Assignee: Sunnybrook Health Sciences Centre
- Current Assignee Address: CA Toronto, Ontario
- Agency: Bereskin & Parr LLP/S.E.N.C.R.L., s.r.l.
- Agent Micheline Gravelle
- Main IPC: A61K35/12
- IPC: A61K35/12 ; A61K35/17 ; C12N5/077 ; C12N5/0789 ; C12N5/0783 ; G01N33/50 ; C12N5/0775
Abstract:
Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
Public/Granted literature
- US20170121684A1 HUMAN PROGENITOR T-CELLS Public/Granted day:2017-05-04
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