Disclosed herein are a signal transmission/reception method for signal analysis in FMMD technology and an apparatus using the method. A signal transmission apparatus includes a signal generation unit for generating two sine wave signals having different frequencies in consideration of a voltage of an excitation coil included in a magnetic particle measurement sensor, a signal addition unit for generating an input signal for producing a magnetic field by electronically adding the two sine wave signals, a differential signal generation unit for generating a differential signal for the input signal to minimize transmission noise, and a signal transmission unit for amplifying voltages of the input signal and the differential signal and transmitting the amplified input signal and differential signal to the excitation coil so as to produce a magnetic field in the excitation coil and apply the magnetic field to a measurement target sample.